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Artykuły medyczne

Tytuł: Zastosowanie jasnego Ichthyolu w dermatologii estetycznej. Kosmetologiczne, jednoośrodkowe, randomizowane, ślepe badanie kontrolowane z użyciem placebo w celu wykazania skuteczności i tolerancji preparatu złożonego: jasny Ichthyol 0,5% i ketokonazol 0,5% w postaci szamponu w porównaniu z ketokonazolem 1,0% w postaci szamponu w leczeniu umiarkowanego i nasilonego łupieżu

Guido Gayko, Jürgen Warnecke, Hana Zelenkova
Prace oryginalne
Dermatologia Kliniczna
Strona początkowa:
Strona końcowa:
Słowa kluczowe:
Ichthyol, ketoconazole, dandruff, erythema, itching, shampoo

Introduction: Sodium Shale Oil Sulfonate (SSOS) with its multifunctional action profile complements the therapeutic class of Ichthyol substances for use in cosmetics. One of their main application fields is treatment of scaling skin diseases. Although dandruff is distinguished by concurrence of a variety of symptoms, it is often treated with anti-fungal substances only. Ketoconazole (KTZ) has become popular in this respect since it can be used in cosmetic application up to a concentration of 2%. In orderto meet the requirements of an integrated approach in this study anti-fungal KTZ was used at a reduced concentration together with SSOS. Aim of the study: The main goal was to find out if a combination of both agents actually offers a better prospect for success of treatment regarding the symptoms scaling, redness and itching interconnected in this skin condition. Material and methods: A randomized double-blind study was conducted on two groups of 12 volunteers using either a 1.0% KTZ shampoo or a combination shampoo (0.5% KTZ and 0.5% SSOS). Subjects were diagnosed as having moderate to severe dandruff. The study consisted of a treatment phase of 8 weeks during which the main objective under assessment was the change in the appearance of dandruff. As secondary objectiveserythema and itching were examined. Results: Asa result, a combination of 0.5% of KTZ and 0.5% of SSOSturned out to be aseffective as 1% of KTZalone in reducing dandruff. However, faster response times to concomitant symptoms redness and itching are traced back to the presence of SSOS in the combination shampoo. Conclusion: The results suggest that synergistic effects and better tolerance may be achieved by combining multifunctional SSOS with KTZ.